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Studies on Chemical Synthesis of Peptides: Efficient Synthetic Methods for β-Amino Acids, Azides, Amino Acid Hydroxamates and Esters

Methodologies in peptide synthesis

Doktorarbeit / Dissertation 2004 180 Seiten

Chemie - Organische Chemie

Zusammenfassung

The importance of ß-amino acids has been focused, particularly in the past few decades. They are found as components of many biologically active peptidic and nonpeptidic natural products with antibiotic, antifungal, cytotoxic, and other pharmacological properties. ß-Amino acids are produced in humans, animals, microorganisms, marine organisms, and plants either in free state or as part of a peptide or depsipeptide. The importance of nonpeptidic ß-amino acids has been nfocused particularly on the ß-lactam antibiotics, since naturally occurring penicillin derivatives have been discovered as broad antibiotic active agents. Over the years, a large number of these compounds have been prepared and tested, and a variety of new ß-lactam ring systems have been introduced such as cephems, cephalosporins, oxacephems, penems, carbapenems, oxapenams as well as monocyclic and polycyclic ring systems. ß-Amino acids have been known to play an important role in primary and secondary metabolism also. [...]

Details

Seiten
180
Jahr
2004
ISBN (eBook)
9783656030454
ISBN (Buch)
9783656036036
Dateigröße
1.6 MB
Sprache
Englisch
Katalognummer
v179845
Institution / Hochschule
Bangalore University / Central College – Department of Studies in Chemistry
Note
Schlagworte
studies chemical synthesis peptides efficient synthetic methods acids azides amino acid hydroxamates esters methodologies

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Titel: Studies on Chemical Synthesis of Peptides: Efficient Synthetic Methods for β-Amino Acids, Azides, Amino Acid Hydroxamates and Esters